long telemeres
Advocates of human life extension promote the idea of lengthening the telomeres in certain cells through temporary activation of telomerase (by drugs). Vitamin D may have an effect on peripheral blood leukocyte telomere length. Richards and coworkers examined whether vitamin D concentrations would slow the rate of shortening of leukocyte telomeres. The authors stated that vitamin D is a potent inhibitor of the proinflammatory response and slows the turnover of leukocytes. As a cell begins to become cancerous, it divides more often and its telomeres become very short. If its telomeres get too short, the cell may die. It can escape this fate by up-regulating an enzyme called telomerase, which can prevent telomeres from getting shorter and even elongate them. Telomerase is the natural enzyme that promotes telomere repair. It is active in stem cells, germ cells, hair follicles, and 90 percent of cancer cells, but its expression is low or absent in somatic cells. Telomerase functions by adding bases to the ends of the telomeres. Cells with sufficient telomerase activity are considered immortal in the sense that they can divide past the Hayflick limit without entering senescence or apoptosis.

1.The more meat you eat the more iodine you are required to have to convert T4 to T3.......a big reason for plateaus....

2.There seems to be a strong positive correlation between high levels of stress hormones and free-radical damage, and both of these correlate negatively with level of telomerase expression and lead to serious disease states.

3.It is not enough to avoid omega 6's grains dairy and fructose and still think this is paleo.......the situation of the host immunity and evolving gut health is always the most important thing to long term viability. If that is intact the host can get away with a lot more than one thinks. 

4.You need feedback from your body to know what paleo really means for your internal metabolic machinery and this answer does not translate to a population......it has a very custom effect. We can draw conclusions from 30000 ft view but there are no rules on what defines paleo for any one person. Context matters.

5.Green tea.....another very paleo thing not talked enough about here. Green tea blocks aromatase enzyme so it increases the sex steroid hormones. Moreover,L-theanine is derived from green tea and crosses the blood-brain barrier. It promotes expression of the neurotransmitter seratonin. There is evidence that l-theanine is neuroprotective, and that it supports relaxation and enhances cognitive function. It appears to decrease the transmission of stimulating neurotransmitters while promoting the transmission of calming neurotransmitters.

6.Another thing I ask my younger paleo's to do is this......maximally eat to protect your brain before the age of 30.....You have to protect you NMDA channels and you must protect against glutamate toxicity in the brain. Excitotoxins destroy the real controller of our metabolism and that is the hypothalamus. Avoid aspartame MSG and sucralose and saccharin at all costs. And if you have used a ton reverse and protect what is left with N acetyl cysteine, tumeric, resveratrol in as high a doses as you can afford. Obviously this is a bigger focus in older paleos i treat but this is huge for young

7.I find it interesting that all of the major risk factors associated with cardiovascular disease (obesity, smoking, poor lipid profile, high blood pressure, diabetes and psychological stress) are associated with key markers of cellular aging (shorter telomere lengths, reduced telomerase activity and higher oxidative damage. That tells me that telomere length is a great measure of what is un paleo......in a sense. Since checking for it is too expensive I use ultra sensitive CRP as a proxy for it because we know it shortens telomeres. Cortisol is another biggie and why I am not a cross fit guy

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 Tolerance is not optimization and optimization is something we should all demand because it leads to disease free states. With the food supply and chain so altered now the only way to navigate that mindfield is to test and see what you can handle and what really is optimal for you. Once optimal is sourced, then "wear" those food stuffs out. – Dr. K Mar 20 at 2:43  
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 I find it interesting that all of the major risk factors associated with cardiovascular disease (obesity, smoking, poor lipid profile, high blood pressure, diabetes and psychological stress) are associated with key markers of cellular aging (shorter telomere lengths, reduced telomerase activity and higher oxidative damage. That tells me that telomere length is a great measure of what is un paleo......in a sense. Since checking for it is too expensive I use ultra sensitive CRP as a proxy for it because we know it shortens telomeres. Cortisol is another biggie and why I am not a cross fit guy – Dr. K Mar 20 at 2:58  
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 So we have much to learn and that is why medicine is an art wrapped in a science. – Dr. K Mar 20 at 3:10  
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 glutamate toxicity = excitotxin damage = leptin resistance.......critical nodes of knowledge here. You need to understand how paleo works from a metabolic 30000 ft level. That is my life's goal.