starving it holds onto fat and begins to eat upon muscle to fuel you. •The ubiquitin-proteasome pathway (UPP) is the predominant catabolic pathway for muscle tissue breakdown. •UPP is increased by excess thyroid, cortisol, low insulin, diet, excess cardiovascular training, and intense resistance exercise. •Inhibitors of UPP are insulin, HMB, arginine, leucine, glutamine, curcumin, and fish oils Natural Hormonal Enhancement(book) Martin Berkhan